The Hotel Principi di Piemonte, designed by architects Vittorio Bonadé Bottino and Giovanni Chevalley, was constructed as part of the urban planning project for the second stretch of the new Via Roma in the 1930s. It remains a pivotal architectural element of the area, alongside the Torre Littoria. Positioned in alignment with Via Bruno Buozzi, perpendicular to the porticoed Via Roma Nuova, the hotel continues to operate as a high-end hotel today.

The building is a compact, monolithic structure featuring a travertine base, which reflects the internal distribution of various service rooms, such as the entrance hall, representative spaces, and public services. This base is topped by an eight-story brick-clad block, which houses the hotel's rooms. The two sections of the facade are separated by an important travertine cornice that echoes the material and geometric ornamentation of the eaves and under-eaves, giving the facade a unified compositional character. The structure is made of reinforced concrete.